In vitro effects of MAZ-51 and epigallocatechin gallate on cellular morphology in B16F10 melanoma cells
Carolyn Nadasen, In vitro effects of MAZ-51 and epigallocatechin gallate on cellular morphology in B16F10 melanoma cells
Winner - University of Pretoria VYT local programme (2023)
Cancer can be described as the growth of cells without any regulatory mechanisms. Specific to Southern Africa, there has been a rising prevalence in cancer cases, emphasizing the need for targeted therapeutics. Current treatments for cancer such as melanoma are not effective, thus leading to the regrowth of cancer cells after treatment. This is where I come in! In my MSc I aim to explore the possible anticancer effects of compounds EGCG and MAZ-51. EGCG is a bioactive catechin found in green tea. MAZ-51 is an antilymphangiogenic factor, meaning that it prevents the spread of cancer cells throughout the lymphatic system. We hypothesize, that these compounds will block the receptors which enable tumour cell proliferation. Thus allowing our compounds to fight and kill the cancer cells. In my study I also look at the effects of these compounds on cellular morphology as this will help us understand the type of mechanistic killing caused by our compounds.